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DUROMINE (PHENTERMINE RESIN): CLINICAL PHARMACOLOGY

Pharmacodynamic properties

Phentermine Resin (Duromine) is a sympathomimetic amine with significant anorectic activity in animal models. Its appetite suppressant effect is generally considered to be exerted through the hypothalamus, but it is not certain that this is the only effect related to weight loss. Phentermine has major effects on the dopaminergic and noradrenergic nervous systems. The cardiovascular effects include a pressor response and increase in heart rate and force of contraction.

Pharmacokinetic properties

Absorption of Phentermine Resin (Duromine) is almost complete. The rate of absorption from the resin complex is significantly slower than that from the hydrochloride salt resulting in a lower and later peak blood level. Phentermine is readily absorbed from the gastro-intestinal tract. Following an oral dose of phentermine capsule, one study demonstrated urinary excreti on of unchanged drug ranging from 62.7% to 84.8% in 72 hours. The remainder is metabolised in the liver. The half-life of phentermine is about 25 hours. In one study in volunteers acidification of the urine reduced the half-life to 7 - 8 hours.



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Digrasil - Orlistat
  • Capsules; Oral; Orlistat 120 mg
  • Lafrancol Laboratorio
  • Acomplia clinical pharmacology - Rimonabant
  • Tablets, Film-Coated; Oral; Rimonabant 20 mg
  • Sanofi-Aventis
  • Vistor


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