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DUROMINE (PHENTERMINE RESIN): PRESCRIBING INFORMATION
Each Duromine capsule contains phentermine as an ion-exchange resin complex equivalent to 15, 30 or 40 mg phentermine depending on strength. The ion-exchange resin is quite stable, highly insoluble and without pharmacological effect until it reacts with cations (potassium, sodium, hydrogen, etc.) present in the gastrointestinal fluids. Phentermine is then released from the resin complex at a rate dependent on the total concentration of these cations. Since this concentration is fairly constant throughout the entire gastrointestinal tract, continuous and controlled ionic release occurs over a 10 to 14 hour period.
Each Duromine capsule also contains inactive ingredients: liquid paraffin, lactose, magnesium stearate, titanium dioxide, gelatin, iron oxide black (CI 77499).
Duromine 15 also contains brilliant iron oxide yellow (CI 77492), blue FCF (CI 42090)
Duromine 30 also contains iron oxide red (CI 77491)
Duromine 40 also contains sunset yellow FCF (CI 15985), erythrosine (CI 45430)
Duromine (Phentermine Resin Complex) capsules are gluten-free
Duromine clinical pharmacology
INDICATIONS AND USAGE
Duromine (Phentermine Resin Complex) capsules is an anorectic agent indicated in the management of obesity as a short-term adjunct in a medically monitored comprehensive regimen of weight reduction based, for example, on exercise, diet (caloric / kilojoule restriction) and behaviour modification in obese patients with a body mass index (BMI) of 30 kg/m2 or greater. The treatment with Duromine can be initiated in overweight patients with a lower BMI (25 to 29.9 kg/m2), which increases the risk of morbidity from a number of disorders. Secondary organic causes of obesity should be excluded by diagnosis before prescribing this agent.
Pulmonary artery hypertension; existing heart valve abnormalities or heart murmurs; moderate to severe arterial hypertension; cerebro-vascular disease; severe cardiac disease including arrhythmias, advanced arteriosclerosis; hyperthyroidism; agitated states or a history of psychiatric illnesses including anorexia nervosa and depression; known hypersensitivity to sympathomimetic drugs; glaucoma; history of drug/alcohol abuse or dependence; concomitant treatment with Monoamine Oxidase Inhibitors or within 14 days following their administration.
Duromine adverse reactions
DOSAGE AND ADMINISTRATION
Duromine dosage and administration
Duromine capsules, 15 mg (grey and green, marked "Duromine 15" on cap and body) 30's
Duromine capsules, 30 mg (grey and reddish brown, marked "Duromine 30" on cap and body) 30's
Duromine capsules, 40 mg (grey and orange, marked "Duromine 40" on cap and body) 30's.
Manufactured and distributed by: iNova Pharmaceuticals company.
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