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IONAMIN (PHENTERMINE RESIN COMPLEX): OVERDOSAGE

Manifestations of acute overdosage may include tremor, restlessness, hyperreflexia, confusion, rapid respiration, assaultiveness, panic states, hallucinations.

Fatigue and depression usually follow the central stimulation.

Cardiovascular effects include hypertension, hypotension, arrhythmias, circulatory collapse.

Gastrointestinal symptoms include nausea, vomiting, abdominal cramps, diarrhea. Overdosage of pharmacologically similar compounds has resulted in fatal poisoning, usually terminating in convulsions and coma.

Management of acute intoxication by Ionamin (Phentermine Resin Complex) is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Intravenous phentolamine (Regitine) has been suggested on pharmacologic grounds for possible acute, severe hypertension, if this complicates overdosage.



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